This disposable tissue grinding system incorporates a patented closed system that grinds the specimen in a sealed container, preventing any risk of contact with the sample. The narrow pestle design eliminates the problem of sample overflow common with other systems and the molded-in abrasive surface leaves no sediment to obstruct the sample during examination. The system arrives fully assembled and gamma sterilized. An extra cap and identification label are provided for sample storage or transport. The unique cap design prevents the unit from rolling when placed on the bench. The 35mL grinder is freestanding, allowing easier handling. All sizes are supplied in cases of 10.